Key publications from our staff

19 November 2017 in Scientific publications

Giedrius Kalesnykas, Emmi Kokki, Laura Alasaarela, Hanna P. Lesch, Timo Tuulos, Kati Kinnunen, Hannu Uusitalo, Kari Airenne and Seppo Ylä-Herttuala. Comparative Study of Adeno-associated Virus, Adenovirus, Baculovirus and Lentivirus Vectors for Gene Therapy of the Eyes. Curr Gen Ther 2017 Volume 17. DOI: 10.2174/1566523217666171003170348

Leinonen H, Keksa-Goldsteine V, Ragauskas S, Kohlmann P, Singh Y, Savchenko E, Puranen J, Malm T, Kalesnykas G, Koistinaho J, Tanila H, Kanninen KM. Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy. Sci Rep. 2017 May 9;7(1):1597. doi: 10.1038/s41598-017-01716-1.

Maciulaitiene R, Pakuliene G, Kaja S, Pauza DH, Kalesnykas G, Januleviciene I. Glioprotection of retinal astrocytes after intravitreal administration of memantine in the mouse optic nerve crush model. Med Science Monitor. 2017; 23:1173-1179.

Hakkarainen JJ, Reinisalo M, Ragauskas S, Seppänen A, Kaja S, Kalesnykas G. Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells. International Journal of Pharmaceutics 2016; 511:73-78.

Vaajanen A, Kalesnykas G, Vapaatalo H, Uusitalo H. The expression of Mas-receptor of the renin-angiotensin system in the human eye. Graefes Arch Clin Exp Ophthalmol. 2015 Jul;253(7):1053-9.

Ragauskas S, Leinonen H, Puranen J, Rönkkö S, Nymark S, Gurevicius K, Lipponen A, Kontkanen O, Puoliväli J, Tanila H, Kalesnykas G. Early Retinal Function Deficit without Prominent Morphological Changes in the R6/2 Mouse Model of Huntington’s Disease. PLoS One. 2014 Dec 3;9(12):e113317.

Tuomela A, Liu P, Puranen J, Rönkkö S, Laaksonen T, Kalesnykas G, Oksala O, Ilkka J, Laru J, Järvinen K, Hirvonen J, Peltonen L. Brinzolamide nanocrystal formulations for ophthalmic delivery: reduction of elevated intraocular pressure in vivo. Int J Pharm. 2014 Jun 5;467(1-2):34-41.

Kalesnykas G, Rawal AS, Kaja S. The Need for Relevant Functional Endpoints in Ophthalmic Drug Discovery. Austin J Clin Ophthalmol. 2014; 1(6):2.

Kaja S, Naumchuk Y, Grillo SL, Borden PK, Koulen P. Differential up-regulation of Vesl-1/Homer 1 protein isoforms associated with decline in visual performance in a preclinical glaucoma model. Vision Res. 2014 Jan;94:16-23.

Payne AJ, Kaja S, Naumchuk Y, Kunjukunju N, Koulen P. Antioxidant drug therapy approaches for neuroprotection in chronic diseases of the retina. Int J Mol Sci. 2014 Jan 27;15(2):1865-86.

Wahlin KJ, Enke RA, Fuller JA, Kalesnykas G, Zack DJ, Merbs SL. Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death. PLoS One. 2013 Nov 11;8(11):e79140.

Burroughs SL, Duncan RS, Rayudu P, Kandula P, Payne AJ, Clark JL, Koulen P, Kaja S. Plate reader-based assays for measuring cell viability, neuroprotection and calcium in primary neuronal cultures. J Neurosci Methods. 2012 Jan 15;203(1):141-5.

Kalesnykas G, Oglesby EN, Zack DJ, Cone FE, Steinhart MR, Tian J, Pease ME, Quigley HA. Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma. Invest Ophthalmol Vis Sci. 2012 Jun 22;53(7):3847-57.

Kaja S, Goad DL, Ali F, Abraham A, Rebenitsch RL, Teymoorian S, Krishna R, Koulen P. Evaluation of tensile strength of tissue adhesives and sutures for clear corneal incisions using porcine and bovine eyes, with a novel standardized testing platform. Clin Ophthalmol. 2012;6:305-9.

Oglesby E, Quigley HA, Zack DJ, Cone FE, Steinhart MR, Tian J, Pease ME, Kalesnykas G. Semi-automated, quantitative analysis of retinal ganglion cell morphology in mice selectively expressing yellow fluorescent protein. Exp Eye Res. 2012 Mar;96(1):107-15.

Kaja S, Hilgenberg JD, Everett E, Olitsky SE, Gossage J, Koulen P. Effects of dilution and prolonged storage with preservative in a polyethylene container on Bevacizumab (Avastin™) for topical delivery as a nasal spray in anti-hereditary hemorrhagic telangiectasia and related therapies. Hum Antibodies.
2011;20(3-4):95-101.

Burroughs SL, Kaja S, Koulen P. Quantification of deficits in spatial visual function of mouse models for glaucoma. Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3654-9.

Niittykoski M, Kalesnykas G, Larsson KP, Kaarniranta K, Akerman KE, Uusitalo H. Altered calcium signaling in an experimental model of glaucoma. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6387-93.

Viita H, Kinnunen K, Eriksson E, Lähteenvuo J, Babu M, Kalesnykas G, Heikura T, Laidinen S, Takalo T, Ylä-Herttuala S. Intravitreal adenoviral 15-lipoxygenase-1 gene transfer prevents vascular endothelial growth factor A-induced neovascularization in rabbit eyes. Hum Gene Ther. 2009 Dec;20(12):1679-86.

Kinnunen K, Kalesnykas G, Mähönen AJ, Laidinen S, Holma L, Heikura T, Airenne K, Uusitalo H, Ylä-Herttuala S. Baculovirus is an efficient vector for the transduction of the eye: comparison of baculovirus- and adenovirus-mediated intravitreal vascular endothelial growth factor D gene transfer in the rabbit eye. J Gene Med. 2009 May;11(5):382-9.

Kalesnykas G, Tuulos T, Uusitalo H, Jolkkonen J. Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models. Neuroscience. 2008 Aug 26;155(3):937-47.

Kalesnykas G, Niittykoski M, Rantala J, Miettinen R, Salminen A, Kaarniranta K, Uusitalo H. The expression of heat shock protein 27 in retinal ganglion and glial cells in a rat glaucoma model. Neuroscience. 2007 Dec 12;150(3):692-704.

Kalesnykas G, Uusitalo H. Comparison of simultaneous readings of intraocular pressure in rabbits using Perkins handheld, Tono-Pen XL, and TonoVet tonometers. Graefes Arch Clin Exp Ophthalmol. 2007 May;245(5):761-2.