EAE/MS model

24 February 2018 in In Vivo

Experimental autoimmune encephalomyelitis/multiple sclerosis (EAE/MS) model

incl. validated functional endpoints for optic neuritis (ON)

Species: mouse
Follow-up period: up to 35 days
Route of compound administration: topical, intravitreal, systemic
Functional and histological read-outs:
• In vivo imaging (optical coherence tomography (OCT))
• In vivo functional assessment: a) electroretinography (pERG), b) visual evoked potentials (VEP)
• Morphological assessment (histology, IHC, EM, stereology)
• Molecular biology (ELISA, Western blotting, qPCR)

Reference compounds (for MS-associated and ON phenotypes)

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