Optic nerve damage
Species: mouse and rat.
Follow-up period: typically 1-2 weeks
Severe loss of retinal ganglion cells and their axons
Route of compound administration: topical, intravitreal, subretinal, systemic
• In vivo imaging (fundoscopy, optical coherence tomography (OCT))
• In vivo functional assessment: a) electroretinography (ERG), b) visual evoked potential measurements (VEP)
• Morphological assessment (histology, IHC, EM, stereology)
• Molecular biology (ELISA, Western blotting, qPCR)
Kalesnykas G, Oglesby EN, Zack DJ, Cone FE, Steinhart MR, Tian J, Pease ME, Quigley HA. Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma. Invest Ophthalmol Vis Sci. 2012 Jun 22;53(7):3847-57.
Leinonen HO, Ragauskas S, Tanila H, Kalesnykas G. Simultaneous pattern ERG-VEP recording after optic nerve crush in albino rats. ARVO 2016, abstract no.: 5763.
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