Optic nerve damage

19 November 2017 in In Vivo

Species: mouse and rat.
Follow-up period: typically 1-2 weeks
Severe loss of retinal ganglion cells and their axons
Route of compound administration: topical, intravitreal, subretinal, systemic
Read-outs:
• In vivo imaging (fundoscopy, optical coherence tomography (OCT))
• In vivo functional assessment: a) electroretinography (ERG), b) visual evoked potential measurements (VEP)
• Morphological assessment (histology, IHC, EM, stereology)
• Molecular biology (ELISA, Western blotting, qPCR)

Our reference:
Kalesnykas G, Oglesby EN, Zack DJ, Cone FE, Steinhart MR, Tian J, Pease ME, Quigley HA. Retinal ganglion cell morphology after optic nerve crush and experimental glaucoma. Invest Ophthalmol Vis Sci. 2012 Jun 22;53(7):3847-57.

Leinonen HO, Ragauskas S, Tanila H, Kalesnykas G. Simultaneous pattern ERG-VEP recording after optic nerve crush in albino rats. ARVO 2016, abstract no.: 5763.

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