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Advances in In Vivo multimodal imaging in the mouse laser-induced choroidal neovascularization model

posted on January 29, 2018

Kuopio, January 29th, 2018.

A team of scientists from Experimentica Ltd., Leica Microsystems, Spective LLC and Loyola University Chicago have published a detailed protocol describing technological advances that allow for the longitudinal in vivo follow-up in a mouse model for age-related macular degeneration (AMD). Specifically, the group used fluorescein angiography and spectral domain optical coherence tomography to track the development of neovascular and fibrotic processes in the laser-induced choroidal neovascularization (CNV) model. The article has been published by the Journal of Visualized Experiments.

"The use of the latest state-of-the-art multimodal imaging techniques is especially useful in therapeutic studies requiring high-throughput-like screening of CNV pathology", comments Dr. Giedrius Kalesnykas, CEO of Experimentica Ltd. "Employing this methodology yields the quantitative, longitudinal in vivo data that many of our sponsors are looking for".

Experimentica Ltd. is a global contract research organization specialized in ocular models. Headquartered in Kuopio, Finland, Experimentica Ltd. focuses on Advancing Ophthalmic Drug DiscoveryTM by offering an industry-leading portfolio for ophthalmic drug development.