Species: C57Bl/6J mice
Follow-up period: typically up to 7 days
Loss of photoreceptors
Route of compound administration: topical, intravitreal, subretinal, systemic
• In vivo imaging (fundoscopy, optical coherence tomography (OCT))
• In vivo functional assessment: a) electroretinography (ERG)
• Morphological assessment (histology, IHC, EM, stereology)
• Molecular biology (ELISA, Western blotting, qPCR)
Ragauskas S, Grüner S, Collin L, Kalesnykas G. Subretinal injection of poly(IC) causes acute photoreceptor cell death in the mouse retinal detachment model. ARVO 2016, abstract no.: 5377.
Matsumoto H, Miller J, Vavvas DG. Retinal detachment model in rodents by subretinal injection of sodium hyaluronate. J. Vis. Exp. (79), e50660, doi:10.3791/50660 (2013).
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