Retinal detachment

19 November 2017 in In Vivo

Species: C57Bl/6J mice
Follow-up period: typically up to 7 days
Loss of photoreceptors
Route of compound administration: topical, intravitreal, subretinal, systemic
Read-outs:
• In vivo imaging (fundoscopy, optical coherence tomography (OCT))
• In vivo functional assessment: a) electroretinography (ERG)
• Morphological assessment (histology, IHC, EM, stereology)
• Molecular biology (ELISA, Western blotting, qPCR)

Our reference:

Ragauskas S, Grüner S, Collin L, Kalesnykas G. Subretinal injection of poly(IC) causes acute photoreceptor cell death in the mouse retinal detachment model. ARVO 2016, abstract no.: 5377.

Reference:

Matsumoto H, Miller J, Vavvas DG. Retinal detachment model in rodents by subretinal injection of sodium hyaluronate. J. Vis. Exp. (79), e50660, doi:10.3791/50660 (2013).

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