Ex vivo retinal neurodegeneration assay
Species: adult mouse and adult rat
Cultivated under ex vivo conditions: up to 10 days
Extent of damage: severe loss of photoreceptors. Gradual loss of retinal ganglion cells
Compound administration: culture medium (ex vivo)
• Ex vivo functional assessment: multi-electrode array system (MEA)
• Morphological assessment (histology, IHC, stereology)
• Molecular biology (ELISA, Western blotting, qPCR)
Nymark S, Ragauskas S, Savolainen V, Holme A, Hyttinen JAK, Kalesnykas G. Morphological and functional characterization of ex vivo retinal explants from adult mice. Investigative Ophthalmology & Visual Science April 2014, Vol.55, 2377.
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