Ischemia

22 September 2017 in In Vivo

A rat model of permanent bilateral common carotid artery occlusion.

Species: rat
Follow-up period: typically up to 5 days
Extent of damage (retinal ganglion cells and their axons): up to 50%
Route of compound administration: topical, intravitreal, subretinal, systemic
Read-outs:
• In vivo imaging (fundoscopy, optical coherence tomography (OCT))
• In vivo functional assessment: a) electroretinography (ERG)
• Morphological assessment (histology, IHC, EM, stereology)
• Molecular biology (ELISA, Western blotting, qPCR)

Our reference:
Kalesnykas G, Tuulos T, Uusitalo H, Jolkkonen J. Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models. Neuroscience. 2008 Aug 26;155(3):937-47.

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