A rat model of permanent bilateral common carotid artery occlusion.
Follow-up period: typically up to 5 days
Extent of damage (retinal ganglion cells and their axons): up to 50%
Route of compound administration: topical, intravitreal, subretinal, systemic
• In vivo imaging (fundoscopy, optical coherence tomography (OCT))
• In vivo functional assessment: a) electroretinography (ERG)
• Morphological assessment (histology, IHC, EM, stereology)
• Molecular biology (ELISA, Western blotting, qPCR)
Kalesnykas G, Tuulos T, Uusitalo H, Jolkkonen J. Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models. Neuroscience. 2008 Aug 26;155(3):937-47.
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