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Category: Custom R&D models

Experimentica’s in vitro team combines decade’s of experience in cellular models, biomarker discovery and imaging modalities to provide you with state-of-the-art biomarker identification and detection in in vitro and in vivo models.

We look forward to discussing your specific project with you and designing a dedicated experimental strategy, conducting any needed pilot experiments, and assisting you with the data analysis.

Our team of scientists has a strong track-record in biomarker detection and imaging modalities in the ophthalmic and neuroscience space and access to state-of-the-art equipment, so you can always be assured that your project will be conducted to your specifications.

SUMMARY

Models

Cell lines, primary cells, tissue and biopsy samples, in vivo models.

In vitro insults

TBD

Read-outs
  • Multiplex immunoassays (Luminex);
  • ELISA;
  • Quantitative PCR;
  • High resolution confocal microscopy;
  • Electron microscopy;
  • Whole-cell patch-clamp electrophysiology.
Examples

The following is a non-comprehensive list of the type of custom project we routinely conduct:

  • Identification of target gene and/or protein expression in specific tissues or regions;
  • Cytokine analysis in tissues, e.g. corneal tissue from our dry eye disease model;
  • Changes of protein expression and distribution in animals models for ophthalmic disease, aging, neurodegeneration and inflammation by confocal microscopy;
  • Determination of barrier integrity using imaging modalities  (e.g. blood-retinal barrier, blood-brain barrier).
Please contact us, if you would like to receive more information: info@experimentica.com

IMAGES

Representative examples from primary rat optic nerve head astrocytes

ONHA assessment

Oxidative stress and cell viability in primary optic nerve head astrocytes

SELECTED PUBLICATIONS

REFERENCES

LATEST NEWS

Refinement of the EAE Mouse Model

Experimental Autoimmune Encephalomyelitis (EAE) is used to study Multiple Sclerosis (MS) a chronic neuroinflammatory demyelinating disorder of the CNS. EAE ... Read More

Novel model for corneal permeability in vitro testing through the combined use of collagen-based hydrogels with stratified corneal epithelial cells

The cornea is critical for penetration of topically applied drugs into the eye. Assessment of the permeability properties of drug ... Read More

A synthetic metalloporphyrin SOD mimetic protects corneal epithelial cells from oxidative stress-induced damage in vitro and in vivo

Keratoconjunctivitis sicca (KCS) is a multifactorial disease of the lacrimal glands and ocular surface1. Pathological findings in patients with KCS ... Read More

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