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Category: Custom R&D projects

Experimentica’s Research & Development Division is actively implementing in vitro models previously described in the scientific literature for a number of customer oriented approaches. Some of our current activities include the development of artificial corneas for permeability screening.

Utilizing cell biology (using primary cells and cell lines), molecular biology, immunocytochemical imaging and multi-mode microplate reader applications, we are able to measure several molecular mechanisms, protein expressions and cellular functions.

We look forward to an opportunity to partner with you to refine or develop almost any custom in vitro project.

IMAGES

In vitro models

Representative examples from our in vitro models (immunohistohcemistry, histology, brightfield microscopy, electron microscopy)

SELECTED PUBLICATIONS

  • Maruotti J, Wahlin K, Gorrell D, Bhutto I, Lutty G, Zack DJ. A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med. 2013,2(5):341-354. doi: 10.5966/sctm.2012-0106.
  • Araki-Sasaki K, Ohashi Y, Sasabe T, Hayashi K, Watanabe H, Tano Y, Handa H. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci 1995,36:614–621.

REFERENCES

  • Hakkarainen JJ, Reinisalo M, Ragauskas S, Seppänen A, Kaja S, Kalesnykas G. Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells. Int J Pharm. 2016;511(1):73-78. doi: 10.1016/j.ijpharm.2016.06.135.

  • Hakkarainen JJ, Maruotti J, Seppänen, Onteniente B, Kalesnykas G, Reinisalo M. hiPSC-derived RPE cells: Characterization of blood-retinal barrier properties and drug permeability. ARVO2016 Poster. Invest. Ophthalmol. Vis. Sci. 2016, Vol.57, 268.

LATEST NEWS

A retinal organotypic model for ex vivo neuroprotection studies

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A recently published study by Experimentica Ltd. and its collaborators from the University of Tampere, Finland, shows that when the ... Read More

Thank you for visiting us at ARVO 2019 conference

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Created by Simon Kaja on   June 5, 2019   in category: News Thank you, everyone, for visiting our booth at ARVO 2019 in Vancouver, Canada, ... Read More

Meet Experimentica team at ARVO 2019

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Visit our booth #1354 or email to set up a one-on-one meeting ... Read More

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