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Category: Custom R&D projects

Experimentica’s Research & Development Division is actively implementing in vitro models previously described in the scientific literature for a number of customer oriented approaches. Some of our current activities include the development of artificial corneas for permeability screening.

Utilizing cell biology (using primary cells and cell lines), molecular biology, immunocytochemical imaging and multi-mode microplate reader applications, we are able to measure several molecular mechanisms, protein expressions and cellular functions.

We look forward to an opportunity to partner with you to refine or develop almost any custom in vitro project.

IMAGES

In vitro models

Representative examples from our in vitro models (immunohistohcemistry, histology, brightfield microscopy, electron microscopy)

SELECTED PUBLICATIONS

  • Maruotti J, Wahlin K, Gorrell D, Bhutto I, Lutty G, Zack DJ. A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med. 2013,2(5):341-354. doi: 10.5966/sctm.2012-0106.
  • Araki-Sasaki K, Ohashi Y, Sasabe T, Hayashi K, Watanabe H, Tano Y, Handa H. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci 1995,36:614–621.

REFERENCES

  • Hakkarainen JJ, Reinisalo M, Ragauskas S, Seppänen A, Kaja S, Kalesnykas G. Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells. Int J Pharm. 2016;511(1):73-78. doi: 10.1016/j.ijpharm.2016.06.135.

  • Hakkarainen JJ, Maruotti J, Seppänen, Onteniente B, Kalesnykas G, Reinisalo M. hiPSC-derived RPE cells: Characterization of blood-retinal barrier properties and drug permeability. ARVO2016 Poster. Invest. Ophthalmol. Vis. Sci. 2016, Vol.57, 268.

LATEST NEWS

Refinement of the EAE Mouse Model

Experimental Autoimmune Encephalomyelitis (EAE) is used to study Multiple Sclerosis (MS) a chronic neuroinflammatory demyelinating disorder of the CNS. EAE ... Read More

Novel model for corneal permeability in vitro testing through the combined use of collagen-based hydrogels with stratified corneal epithelial cells

The cornea is critical for penetration of topically applied drugs into the eye. Assessment of the permeability properties of drug ... Read More

A synthetic metalloporphyrin SOD mimetic protects corneal epithelial cells from oxidative stress-induced damage in vitro and in vivo

Keratoconjunctivitis sicca (KCS) is a multifactorial disease of the lacrimal glands and ocular surface1. Pathological findings in patients with KCS ... Read More

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