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Category: Custom R&D projects

Experimentica’s Research & Development Division is actively implementing in vitro models previously described in the scientific literature for a number of customer oriented approaches. Some of our current activities include the development of artificial corneas for permeability screening.

Utilizing cell biology (using primary cells and cell lines), molecular biology, immunocytochemical imaging and multi-mode microplate reader applications, we are able to measure several molecular mechanisms, protein expressions and cellular functions.

We look forward to an opportunity to partner with you to refine or develop almost any custom in vitro project.

IMAGES

In vitro models

Representative examples from our in vitro models (immunohistohcemistry, histology, brightfield microscopy, electron microscopy)

SELECTED PUBLICATIONS

  • Maruotti J, Wahlin K, Gorrell D, Bhutto I, Lutty G, Zack DJ. A simple and scalable process for the differentiation of retinal pigment epithelium from human pluripotent stem cells. Stem Cells Transl Med. 2013,2(5):341-354. doi: 10.5966/sctm.2012-0106.
  • Araki-Sasaki K, Ohashi Y, Sasabe T, Hayashi K, Watanabe H, Tano Y, Handa H. An SV40-immortalized human corneal epithelial cell line and its characterization. Invest Ophthalmol Vis Sci 1995,36:614–621.

REFERENCES

  • Hakkarainen JJ, Reinisalo M, Ragauskas S, Seppänen A, Kaja S, Kalesnykas G. Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells. Int J Pharm. 2016;511(1):73-78. doi: 10.1016/j.ijpharm.2016.06.135.

  • Hakkarainen JJ, Maruotti J, Seppänen, Onteniente B, Kalesnykas G, Reinisalo M. hiPSC-derived RPE cells: Characterization of blood-retinal barrier properties and drug permeability. ARVO2016 Poster. Invest. Ophthalmol. Vis. Sci. 2016, Vol.57, 268.

LATEST NEWS

New Board of Directors announced

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Experimentica Ltd., a global contract research organization that specializes in preclinical models for ophthalmic diseases, is pleased to announce its ... Read More

New insights to the supporting mechanism of fluid management in the neural retina

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Angiopoietin-4 was identified as the first growth factor having a venous-specific function in the mouse retina, according to a publication ... Read More

Experimentica Ltd. opens a new R&D site in Lithuania

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The investment totaling €1.6 million was supported, in part, by a competitive award “Smart FDI” (project no. 01.2.1-LVPA-T-848-01-005) under the ... Read More

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