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Category: Tolerability and Toxicity Studies
Animals used for research:  Mouse, Rabbit, Rat 

At Experimentica Ltd., we utilize our expertise in longitudinal in vivo imaging and electrophysiology of the visual system to offer the most comprehensive and in-depth assessment of ocular tolerability and toxicity.

All our tolerability and toxicity studies can be conducted with GLP-like or certified GLP documentation.

SUMMARY

Animal species

Mice, Rats, Rabbits

Follow-up period

Tolerability: 1 hr, 4hr, 8 hr, 24, hr, 48 hr, 72 hr, 96 hr, 120 hr
Single dose toxicity: days to months
Repeated dose toxicity: months

Typical size of one treatment group

5 – 20

Route of compound administration

Intravitreal, topical, systemic

Read-outs
  • Standard systemic tolerability readouts
  • Dedicated ocular tolerability readouts, including:
    • Slit-lamp exam
    • Applanation tonometry
    • Spectral-domain ocular coherence tomography
    • Fluorescence angiography
    • Vitreofluorophotometry
    • Electroretinography
  • Histopathology
Please contact us, if you would like to receive more information: info@experimentica.com

IMAGES

Ocular Toxicity and Tolerability Studies at Experimentica Ltd.

SELECTED PUBLICATIONS

Draize JH, Kelley EA. Toxicity to eye mucosa of certain cosmetic preparations containing surface-active agents. Proc Sci Sec Toilet Goods Assoc 1952; 17:1-4.

REFERENCES

Wilhelmus KR. The Draize eye test. Surv Ophthalmol 2001;45(6):493-515.