Advances in preclinical in vivo imaging: OCT-Angiography of the rat retina

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By Experimentica on October 7, 2019
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Summary: Optical Coherence Tomography Angiography (OCT-A) is a novel non-invasive imaging technique to generate high resolution images of the retinal and choroidal microvasculature. By using motion contrast imaging, OCT-A can generate angiographic images without the need for intravenous dye injection.

Advances in preclinical in vivo imaging: OCT-Angiography of the rat retina

Optical Coherence Tomography Angiography (OCT-A) is a novel non-invasive imaging technique to generate high resolution images of the retinal and choroidal microvasculature. By using motion contrast imaging, OCT-A can generate angiographic images without the need for intravenous dye injection.

At Experimentica, we are now implementing the use of OCT-A to quantify disease-associated changes in the microvasculature. Leveraging our ongoing efforts in artificial intelligence (AI) and machine learning, we anticipate that rodent OCT-A images will further improve the translatability from preclinical disease models in the very near future.

The OCT-A scans shown here were captured using the Spectralis® OCT-A module (Heidelberg Engineering, Germany). The animation shows the 3D rendering of a single scan from a naïve rat with representative still images obtained from the superficial vascular complex and the deep capillary plexus.   

Contact for media enquiries:

Dr. Leona Damalakiene
R&D Director
Experimentica Ltd.
Phone: +370 (686) 14 280
Email: leona@experimentica.com

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