Neuroscience 2022 – Involvement of the elastin synthesis pathway in reactive astrocytosis in primary optic nerve head astrocytes

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By Experimentica on November 10, 2022

Summary: Simon Kaja, PhD, CSO & VP, Americas of Experimentica will present at SfN’s Neuroscience 2022.


Lysl-Oxidase-Like1 (LOXL1) is a critical enzyme required for elastin biogenesis and collagen cross-linking, thereby regulating the biomechanical properties of the tissue. Our studies have identified a key role for LOXL1 in reactive astrocytosis resulting in reduced elastin biosynthesis. Our studies support the notion that impaired elastin synthesis in glaucoma may be responsible, in part, for impaired neuron-glia signaling that drives disease progression.

Key takeaway:

  • Glaucomatous insults alter elastin synthesis in optic nerve head astrocytes through LOXL1 modulation
  • Impaired LOXL1 function is sufficient to induce molecular signatures of reactive astrocytosis
  • Reduced elastin synthesis may contribute to impaired neuron-glia signaling in glaucoma

Authors:  Simon Kaja | Harsh Hariani | Vidhya Rao | Anita Ghosh

Attend the presentation:

November 15, 2022, 8:30-8:45am Pacific
San Diego Convention Center, Room 31ABC

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