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Animal Welfare at Experimentica Ltd.

Experimentica Ltd. is committed to following the highest ethical standards to ensure the welfare of animals used in research. We understand that animal research is paramount to developing and testing novel medicines for both humans and animals that are safe and effective. All experimental protocols involving research animals have been reviewed and approved by National Animal.


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EAE/MS model

EAE/MS model for studying MS-associated optic neuritis phenotypes


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Dry eye syndrome

A mouse model for keratoconjuctivitis sicca


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Ex vivo retinal neurodegeneration assay

Efficient compound evaluation on cultured retinal explants under ex vivo conditions


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Neurodegeneration assays on primary neurons

A range of robust assays to evaluate neuroprotection on primary rat cortical neurons


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Ischemia

A rat model of bilateral common carotid artery occlusion


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Glaucoma

Ocular hypertension models: laser (rat), microbead (mouse and rat), DBA2J mice


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Retinopathy of prematurity

A mouse model of oxygen-induced retinopathy (OIR)


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Diabetic retinopathy

Streptozotocin-induced diabetic retinopathy model


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Age-related macular degeneration

Preclinical models for wet and dry forms of age-related macular degeneration


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Optic nerve damage

Optic nerve crush model in mice and rats


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Retinal detachment

Preclinical model of retinal detachment


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Cytotoxicity and permeability assays

Cytotoxicity and permeability assays on primary or hiPSC-derived retinal pigment epithelium (RPE) cells


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Corneal permeation assay

Permeability of test compounds across rabbit cornea (ex vivo) or human corneal epithelial cell layer (in vitro)


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Photoreceptor-specific assays

Retinoblastoma WERI-Rb-1 cell line as an in vitro model for studying photoreceptor-specific cytotoxicity and gene regulation assays


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Corneal epithelial cell cytotoxicity assay

Human corneal epithelial cell viability in evaluating toxic effects of testing compounds and excipients in ocular drops


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In vitro model for glioprotection

Cell viability assays for glioprotection using primary rat optic nerve head astrocytes


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In vitro model for endothelial cell proliferation

Proliferation assay on primary bovine retinal endothelial cells


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