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ARVO 2026 presentation: Superior efficacy of intravitreal dexamethasone implant over systemic and topical corticosteroids in a rabbit model of tnf-a–induced uveitis

ARVO 2026 presentation: Superior efficacy of intravitreal dexamethasone implant over systemic and topical corticosteroids in a rabbit model of tnf-a–induced uveitis

Ocular uveitis is a major cause of vision loss and often requires corticosteroid therapy to control inflammation. Intravitreal administration of tumor necrosis factor alpha (TNF-α) in rabbit eyes causes ocular inflammation in the anterior chamber, iris hyperemia, and vitreal haze. The purpose of this study was to compare the anti-inflammatory efficacy of intravitreal Ozurdex, systemic prednisolone, and topical dexamethasone.

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A mouse model for Dry Eye Disease

A mouse model for Dry Eye Disease

Experimentica utilizes a validated mouse model of dry eye disease. Dry eye disease-like pathology is induced using transdermal scopolamine patches in combination with desiccating environmental stress. The induced pathology is characterized using corneal fluorescein staining, tear volume measurements, and histology for lacrimal gland infiltration, goblet cell loss, and corneal abnormalities.

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Modeling Diabetic Retinopathy in rodents

Modeling Diabetic Retinopathy in rodents

A brief overview of streptozotocin-induced diabetic retinopathy in rodents, highlighting strain-specific differences, quantitative assessment of retinal vascular leakage, identification of the most consistent and reliable readout, and animal welfare considerations.

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