Our expertise

In vivo imaging

Advances in imaging technology have led to the adaptation of clinical imaging systems to the eyes of small laboratory animal species, notably rodents, allowing for the longitudinal high-resolution in life assessment across all species from rodents to pigs.

Spectral domain-optical coherence tomography (SD-OCT) is the most widely used imaging modality in clinical practice and has become the cornerstone of the in vivo assessment of the retina and the anterior segment, including the cornea and the iris, in preclinical safety and efficacy studies.

At Experimentica, we use state-of-the-art imaging equipment, including Bioptigen Envisu (Leica Microsystems) and Spectralis HRA (Heidelberg Engineering) devices to acquire SD-OCT scans. High-resolution scans can be analyzed using commercial software solutions or our proprietary algorithm to derive accurate and unbiased retinal thickness measurements.

Additional imaging modalities, including fluorescein angiography (FA) and specular microscopy, can supplement the SD-OCT structural assessment, e.g. when suspecting vascular toxicity induced by test articles.

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