Disease models
Laser-Induced Choroidal Neovascularization
In 1989, Dobi and colleagues were first to describe a rat Choroidal Neovascularization model (CNV), which was induced using a krypton laser. Rapid development of different in vivo imaging modalities turned this model into a powerful and validated tool for the screening of novel drug candidates with anti-angiogenic and/or anti-fibrotic properties. This model mimics multiple pathological features of exudative age-related macular degeneration (AMD).
Technical details
– An area of retinal leakage (FA)
– An area of isolectin B4 staining from choroidal flat mounts
Scientific excellence in every model
A quick screening of anti-angiogenic properties of your test article
Multiple in vivo imaging timepoints for efficacy detection using our latest state-of-the-art equipment
Unbiased data analysis using proprietary AI-driven algorithms
References
- Dobi ET, Puliafito CA, Destro M. A New Model of Experimental Choroidal Neovascularization in the Rat. Arch Ophthalmol. 1989;107(2):264–269. doi:10.1001/archopht.1989.01070010270035
- Ragauskas S, Kielczewski E, Vance J, Kaja S, Kalesnykas G. In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model. J Vis Exp. 2018 Jan 21;(131):56173. doi: 10.3791/56173
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