Disease models
Sodium Iodate-Induced Retinal Degeneration
The sodium iodate (NaIO3)-induced retinal degeneration model is a widely used tool for investigating age-related macular degeneration (AMD). In this model, NaIO3, administered via intravenous injection, causes oxidative stress that leads to the death of the retinal pigment epithelium (RPE) followed by secondary photoreceptor degeneration, mimicking the progression of AMD.
Our capabilities in this model include advanced non-invasive in vivo imaging techniques, such as fundus autofluorescence (FAF) to monitor retinal degeneration, spectral-domain optical coherence tomography (SD-OCT) for quantitative assessment of individual retinal layer thickness, and flash electroretinography (fERG) to assess retinal function, providing a comprehensive platform for evaluating potential AMD therapies.
Technical details
– Fundus autofluorescence for visualization of damaged area
– Spectral-domain optical coherence tomography for retinal thickness
– Electroretinography for rod bipolar cell function protection
Immunohistochemistry
– RPE65 or other markers
Scientific excellence in every model
Relevance to Human Disease
The model replicates retinal degeneration seen in conditions affecting RPE and photoreceptors (e.g. AMD).
Advanced Monitoring
Non-invasive imaging (OCT, FA) allows detailed structural and functional tracking of retinal changes.
Cost-Effective and Reliable
A well-established, efficient model for preclinical therapy testing in retinal degeneration.
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