Preclinical expertise and advanced ocular models – tailored to your research goals

In vitro permeability

In vitro models using HCE-T and PCi-RPE cells help assess drug permeability by mimicking corneal epithelium and blood-retinal barriers in early drug development.

Flash Electroretinography

Flash ERG is a non-invasive method to assess retinal function in preclinical eye disease models.

Pattern Electroretinography

Pattern ERG is a non-invasive method to assess retinal ganglion cell function and monitor dysfunction in preclinical eye disease models.

Visual Evoked Potentials

Visual evoked potential recording is used to assess visual pathway function from retina to cortex in models of glaucoma and optic neuropathies.

RT-qPCR

qPCR measures gene expression in ocular tissues, supporting disease research and treatment evaluation.

ELISA

ELISA enables sensitive protein detection and quantification in ocular tissues and biofluids.

Western Blotting

Western blot detects protein expression and modifications in ocular tissues with high sensitivity and precision

Optomotor Reflex

Experimentica offers behavioral assessment and optomotor response testing to evaluate visual acuity and contrast sensitivity in rodent models.

In vivo imaging

Experimentica offers extensive in vivo imaging capabilities for high-resolution ocular assessments across species.

AI for image analysis

AI-driven image analysis for in vivo studies, delivering faster, unbiased results and deeper insights for your preclinical ocular programs.

Tissue processing

Specialized processing of ocular and neural tissues employing methods such as flat mounting, paraffin and cryo embedding, and precision sectioning.

Histological staining

Histological staining techniques for ocular and nervous system tissues to support detailed analysis.

Immunohistochemistry

Experimentica offers a wide range of single and multiplex immunofluorescence labeling to explore disease pathogenesis and therapeutic targets.

Streptozotocin-Induced Diabetic Retinopathy

STZ-induced diabetic retinopathy model mimics early-stage human disease and supports long-term in vivo imaging and functional assessment.

Oxygen-Induced Retinopathy

Oxygen-Induced Retinopathy model enables preclinical evaluation of retinal neovascularization and anti-angiogenic therapies.

Blue Light Damage-Induced Retinal Degeneration

The blue light-induced retinal damage model is used for studying phototoxicity-induced retinal degeneration, and is particularly relevant for conditions such as AMD.

Laser-Induced Choroidal Neovascularization

Laser-induced CNV model mimics exudative AMD and supports evaluation of anti-angiogenic and anti-fibrotic therapies.

Sodium Iodate-Induced Retinal Degeneration

The sodium iodate-induced retinal degeneration model mimics AMD progression and supports evaluation of therapies using in vivo imaging techniques.

Desiccating Stress + Scopolamine-Induced Dry Eye

A mouse dry eye model using desiccating stress and pharmacologic inhibition mimics key features of human DED, supporting therapy evaluation through imaging and histological analysis.

Optic Nerve Crush

Optic Nerve Crush model enables evaluation of therapeutic effects on retinal ganglion cell loss and visual function decline using in vivo method.

Microbead-Induced Glaucoma

A well-established glaucoma model simulating chronic IOP elevation and enabling assessment of optic nerve damage and neuroprotective therapies.

Experimental Autoimmune Encephalomyelitis

Experimental Autoimmune Encephalomyelitis model mimics multiple sclerosis and associated optic neuritis, featuring CNS inflammation, demyelination, and visual impairment.

High IOP-Induced Ischemia-Reperfusion Injury

Nonarteritic Anterior Ischemic Optic Neuropathy

NAION rodent model enables in vivo imaging and functional tests to study optic nerve edema, RGC loss, and treatment effects following ischemic injury.

In vitro tube formation assay (HUVECs)

The HUVEC tube formation assay quantifies angiogenesis in vitro by analyzing endothelial response to angiogenic signals and tube formation via imaging.

DL-AAA–Induced Retinal Neovascularization and Chronic Leakage

DL-AAA-induced rabbit model enables long-term evaluation of retinal neovascularization and leakage with in vivo imaging and response to anti-VEGF therapy.

White Light Damage-Induced Retinal Degeneration

White light damage model mimics retinal degeneration, enabling preclinical evaluation of neuroprotective therapies.

Antigen-Induced Uveitis

TNF-α-induced uveitis model in rabbits supports preclinical evaluation of ocular inflammation and anti-inflammatory therapies using clinical grading.

Retinitis Pigmentosa

Retinitis pigmentosa studies at Experimentica combines genetic models with in vivo imaging and molecular analysis tools.

Laser-Induced Glaucoma

Laser-induced ocular hypertension models enable chronic IOP elevation and detailed assessment of glaucomatous damage and therapies.