Summary: Retinal detachment happens in AMD, Diabetic Retinopathy, and Retinopathy of Prematurity.
The detachment of photoreceptors from retinal pigment epithelium is evident in various diseases such as age-related macular degeneration (AMD), diabetic retinopathy (DR) or retinopathy of prematurity (ROP). Detached photoreceptors undergo cellular death, which subsequently leads to visual decline. Subretinal injection of sodium hyaluronate induces retinal detachment (RD) and photoreceptor cells death.1-3
|Method of induction||Subretinal injection|
|Follow-up period||Up to 7 days|
|Route of compound administration||Topical (e.g. eye drops), subretinal, intravitreal, systemic|
|Read-outs||1. In vivo imaging:|
– Fluorescein angiography,
– Optical coherence tomography (OCT),
2. In vivo functional assessment,
3. Morphological assessment,
4. Molecular biology (ELISA, Western blotting, qPCR).
Outcomes and Read-Outs
In vivo imaging
Experimentica uses state-of-the-art in vivo imaging methodologies, which allow the longitudinal evaluation of pathological changes.
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