Summary: NaIO3-induced retinal degeneration is widely used to study cell death in AMD. This results in death of retinal pigmented epithelium followed by a secondary death of photoreceptors, similar to what is observed in Geographic Atrophy.
Age-related macular degeneration (AMD) is the leading cause of central vision loss for people age 50 and older. This vision loss makes it harder to do most of the day-to-day activities, like driving, cooking and reading.
Sodium iodate (NaIO3)-induced retinal degeneration models have been widely used to study the cell death in AMD. Sodium iodate results in death of retinal pigmented epithelium (RPE) followed by a secondary death of photoreceptors, similar to what is observed in atrophic AMD (or geographic atrophy, GA).
|Animal species||Rats, Rabbits|
|Method of induction||Injection of sodium iodate|
|Follow-up period||Typically up to 35 days|
|Route of compound administration||Intravitreal, topical, systemic|
|Read-outs||1. In vivo imaging|
– Fluorescein angiography for damaged area quantification;
– Optical coherence tomography for retinal thickness;
2. Functional assessment:
– Rod bipolar cell function protection.
Outcomes and Capabilities
In vivo imaging
Fluorescein angiography (rabbit; Heideleberg Spectralis). Retinal damage and protection after NaIO3 induction; Graph of area and percentage of damage in the retina.
Retinal thickness measurements (OCT) of rabbits induced with NaIO3.
Rod bipolar cell function protection in NaIO3-induced retinal damage model treated with a high dose FAS inhibitor.
- Kocab AJ, Bacellar-Galdino M, Zacks DN, Jamison JA, Van De Goor J. Inhibition of Fas with ONL 1204 provides protection in a novel rabbit model of dry AMD. 2020. ARVO annual meeting. Poster presentation.