Disease models
Blue Light Damage-Induced Retinal Degeneration
The blue light-induced retinal damage model is widely used for studying phototoxicity and retinal degeneration. Exposure to high-intensity blue light induces oxidative stress, leading to photoreceptor apoptosis, retinal pigment epithelium (RPE) dysfunction, and neuroinflammation (Christian and Remé, 2019).
This model is a valuable tool for evaluating potential therapeutic agents for retinal degeneration, oxidative stress responses, and neuroprotective strategies. It is particularly relevant for conditions such as age-related macular degeneration (AMD) and other retinal diseases associated with light-induced damage (Carozza et al 2024, and Chakravarthy 2024). The blue light model effectively mimics aspects of retinal pathology, making it a useful system for preclinical studies on retinal protection and repair.
Technical details
– Retina functionality from ERG
– Histology and immunohistochemistry
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References
- Carozza, Giulia, Darin Zerti, Annamaria Tisi, Marco Ciancaglini, Mauro Maccarrone, and Rita Maccarone. 2024. “An Overview of Retinal Light Damage Models for Preclinical Studies on Age-Related Macular Degeneration: Identifying Molecular Hallmarks and Therapeutic Targets.” Reviews in the Neurosciences 35 (3): 303–30.
- Chakravarthy, Harshini, Vasil Georgyev, Cole Wagen, Amir Hosseini, and Joanne Matsubara. 2024. “Blue Light-Induced Phototoxicity in Retinal Cells: Implications in Age-Related Macular Degeneration.” Frontiers in Aging Neuroscience 16 (December).
- Grimm, Christian, and Charlotte E. Remé. 2019. “Light Damage Models of Retinal Degeneration.” Methods in Molecular Biology (Clifton, N.J.) 1834:167–78.
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