Disease models
High IOP-Induced Ischemia-Reperfusion Injury
In 1996, Adachi et al. introduced a rat model of high intraocular pressure-induced ischemia and reperfusion injury induced by acutely increasing the intraocular pressure for a period of time (1). Accute increase of the intraocular pressure mimics primary open-angle glaucoma & acute angle-closure glaucoma by causing formation of reactive oxygen species, breakdown of inner blood-retinal barrier, and eventually retinal ganglion cell death.
Recent advancements in in vivo imaging and electrophysiology turned this model into a powerful and validated tool for the screening of novel drug candidates with neuroprotective properties. Further innovations in AI-driven image recognition offers more precise and accurate screening of novel drug candidates.
Technical details
– Inner retinal thickness measurements (SD-OCT)
– Flash and pattern electroretinogram (fERG & pERG)
– Optomotor response (OMR) testing for visual acuity and contrast sensitivity
– Quantitative and unbiased estimation of RGCs from retinal flat mounts
Scientific excellence in every model
Clinically relevant and fast
Models retinal ischemia with measurable neuronal loss within 7–14 days, enabling rapid therapeutic screening.
Precise and versatile
Controlled IOP elevation allows adjustable severity of injury, analyzed for functional and structural insights using SD-OCT, ERG, OMR and histology.
Unbiased assessment
AI-driven image analysis and stereology provide objective, reproducible RGC quantification for reliable drug efficacy assessment.
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