Disease models
Microbead-Induced Glaucoma
In 2011, Samsel and colleagues first described a magnetic microbead-induced elevated intraocular pressure (IOP) model, which was established by injecting magnetic microbeads into the anterior chamber of the eye. This model effectively simulates the gradual IOP elevation seen in glaucomatous neuropathies. The development of advanced in vivo imaging and functional assessment techniques has transformed this model into a reliable and widely used tool for studying the mechanisms of glaucoma and evaluating novel neuroprotective therapies. It closely replicates key aspects of optic nerve damage and retinal ganglion cell degeneration observed in human glaucoma.
Technical details
– Functional assessment of RGCs (pERG)
– Visual acuity and contrast sensitivity (OMR)
– Quantitative estimation of RGCs
Scientific excellence in every model
Chronic IOP elevation
One of the best models to mimic hypertensive glaucoma
Non-invasive monitoring of pathology
Application of 3Rs using in vivo imaging, functional assessment and behavioral analysis
Unbiased quantitative data
From functional to morphological readouts
References
- Samsel, P. A., Kisiswa, L., Erichsen, J. T., Cross, S. D., & Morgan, J. E. (2011). A novel method for the induction of experimental glaucoma using magnetic microspheres. Investigative ophthalmology & visual science, 52(3), 1671-1675.
- Tribble, J. R., Otmani, A., Kokkali, E., Lardner, E., Morgan, J. E., & Williams, P. A. (2021). Retinal ganglion cell degeneration in a rat magnetic bead model of ocular hypertensive glaucoma. Translational Vision Science & Technology, 10(1), 21-21.
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