The main aim of the study was to examine the correlation of ocular hypertension with morphological, functional and behavioural parameters in the mouse magnetic microbead glaucoma model.
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Glaucoma, a leading cause of blindness and visual impairment worldwide, is characterized by progressive loss of retinal ganglion cells (RGCs) and damage to the optic nerve. Neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF), have been extensively studied for their potential to promote RGC survival and axonal regeneration. However, BDNF's efficacy is restricted by receptor desensitization, while CNTF alone often induces inflammation and gliosis, limiting its therapeutic potential. This study was aimed at evaluating if a combination of BDNF and CNTF offers synergistic effects, providing superior neuroprotection as compared to either factor alone.
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This study aimed at comparing blue light-induced retinal injury in albino Balb/cJRj and pigmented C57BL/6JRj mice.
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Limited treatment options for patients with geographic atrophy (GA) pose challenges to find proper positive controls in preclinical models. This study aimed to test the efficacy of subconjunctival administration of triamcinolone in a laser-induced mouse model of GA.
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Intravitreally injected phosphate-buffered saline (PBS) is known to decrease neovascularization in the mouse oxygen-induced retinopathy (OIR) model, and it is commonly used as a vehicle control in preclinical studies evaluating therapeutic efficacy. This study aimed at evaluating the impact of intravitreally (IVT) administered PBS on neovascularization and revascularization at various timepoints after OIR induction. Aflibercept (Eylea®) was used as a reference control.
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Cornea is a tight barrier restricting topically administered drugs’ penetration into the eye. The aim of the study was to create a tight epithelial barrier both with primary and with transformed human corneal cells on a 96-well microfluidic platform.
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Retinal pigment epithelium (RPE) cells exhibit a high susceptibility to reactive oxygen species (ROS) due to their elevated metabolic activity. The accumulation of ROS is a critical factor contributing to the pathogenesis of both dry and wet forms of age-related macular degeneration (AMD). The thioredoxin (TRX) system represents one of the two primary thiol-dependent antioxidant defense mechanisms in mammalian cells. The objective of this study was to investigate the concentration-dependent activation and response of the TRX system to ROS induced by RPE specific exogenous oxidative agent, sodium iodate (NaIO3).
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To date, ocular injections and implants are the most effective methods for drug delivery to the back of the eye. However, invasive delivery methods also are costly and risky due to possible complications. In this paper, a novel proprietary polyacetylene polymer and two cell penetrating peptides are compared for topical drug delivery to treat retinal diseases.
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Examining the link between retinal function and structure in ocular hypertension is crucial for glaucoma research. The rat magnetic microbead model, mimicking glaucoma aspects, provides insights into this relationship. The study aims to examine if behavioral, functional, and morphological parameters have correlation in the rat magnetic microbead glaucoma model.
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Streptozotocin (STZ) induced hyperglycemic rats, commonly used in preclinical diabetic retinopathy (DR) research, have poor response to the most used laboratory rodent anesthesia such as medetomidine/ketamine mixture (MK), and are prone to develop various welfare issues. The purpose of this study was to compare medetomidine/midazolam/butorphanol anesthesia (MMB) to MK in the STZ induced DR rat model to validate injectable anesthesia with less side effects and faster recovery time without compromising the DR development.
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