Retinopathy of prematurity
This model is based on the neonatal mouse exposure to hyperoxia during retinal vasculature development (Smith et al., 1994). Hyperoxia causes depletion of capillaries in the central part of retina and upon return to normoxic conditions leads to ischemia and proliferative retinopathy.
Indications: diabetes, retinal ischemia, retinopathy of prematurity (ROP)
Vähätupa M, Uusitalo-Järvinen H, Järvinen T, Uusitalo H, Kalesnykas G. Intravitreal injection of PBS reduces retinal neovascularization in the mouse oxygen-induced retinopathy model. ARVO 2016, abstract no.: 3649.
Smith LEH, Wesolowski E, McLellan A, Kostyk SK, D’Amato R, Sullivan R, and D’Amore PA. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci. 1994, 35:101-111.
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