Disease models
White Light Damage-Induced Retinal Degeneration
The white light-induced retinal damage is widely used for studying retinal degeneration. Exposure to high-intensity white light induces oxidative stress, leading to photoreceptor death, retinal pigment epithelium (RPE) dysfunction, and neuroinflammation (Grimm and Remé, 2019).
This model is a valuable tool for evaluating potential therapeutic agents for retinal degeneration, oxidative stress responses, and neuroprotective strategies. It is particularly relevant for conditions such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) and other retinal diseases associated with light-induced damage (Organisciak and Vaughan, 2010). The white light model effectively mimics aspects of retinal degeneration, making it a useful system for preclinical studies on retinal protection and repair (Cerrada-Gimenez et al, 2024).
Technical details
– Functional assessment using ERG
– Histology and immunohistochemistry
Scienfic excellece in every model
Rapid screening of neuroprotective properties
Quick turnaround and standardized readouts
Comprehensive efficacy evaluation
Advantage of multiple efficacy evaluation timepoints, incl. in vivo imaging and ERG
Advanced and unbiased data
Gain reliable insights through detailed analysis.
References
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Cerrada-Gimenez, Marc, Leena Tähtivaara, Anni Tenhunen, Xavier Ekolle, Birgitta Lappeteläinen, Ville Jokinen, Anne Mari Haapaniemi, et al. 2024. “Dose-Dependent Retinal Damage in a LED White Bright Light Model.” Investigative Ophthalmology & Visual Science 65 (7): 758.
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