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Welfare complications in the male BN/Crl and RjHan:SD rat streptozotocin-induced diabetes models
Scientific publications

Welfare complications in the male BN/Crl and RjHan:SD rat streptozotocin-induced diabetes models

Our latest publication by Anni Tenhunen and colleagues on the welfare outcomes of two widely used rat lines, Brown Norway (BN/Crl) and Sprague Dawley (RjHan:SD), in the STZ-induced diabetic retinopathy model. BN/Crl rats are often favored for ocular studies due to their pigmented eyes, however, our study raises important concerns about their routine use in diabetic models, given their increased risk of serious welfare issues.

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Faster results for in vitro corneal permeability studies
News

Faster results for in vitro corneal permeability studies

At Experimentica, we are committed to advancing R&D and continuously improving established study methods. Our work is guided by three core principles: quality, flexibility, and scientific excellence, all of which support our commitment to be a trusted partner for our clients. In collaboration with Finnadvance Ltd, we validated the AKITA® platform combined with human corneal epithelial cells which has yielded substantial advancements in in vitro corneal permeability studies.

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FELASA 2025 presentation: Assessing lidocaine-based analgesia for mouse ​ear notching: Insights into strain-specific reactions​
News Scientific publications

FELASA 2025 presentation: Assessing lidocaine-based analgesia for mouse ​ear notching: Insights into strain-specific reactions​

From the beginning of 2024, a new national law on animal protection in Finland (1165/2023 3 §) requires laboratory rodent ear notching to be performed only with "appropriate pain relief". However, the European Union directive on the protection of animals used for scientific purposes (2010/63/EU) classifies ear notching as a routine identification method rather than a procedure, leaving no specific guidelines on suitable analgesia at the EU or the national level. This study aimed to evaluate the suitability of a lidocaine-based cream as analgesia (EMLA cream 5%, lidocaine + prilocaine 25+25 mg/g, Aspen Pharmacare Australia) for mice undergoing ear notching.

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ARVO 2025 presentation: Combined administration of BDNF and CNTF provides superior neuroprotection as compared to BDNF alone in a mouse optic nerve crush model
News Scientific publications

ARVO 2025 presentation: Combined administration of BDNF and CNTF provides superior neuroprotection as compared to BDNF alone in a mouse optic nerve crush model

Glaucoma, a leading cause of blindness and visual impairment worldwide, is characterized by progressive loss of retinal ganglion cells (RGCs) and damage to the optic nerve. Neurotrophic factors, including brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF), have been extensively studied for their potential to promote RGC survival and axonal regeneration. However, BDNF's efficacy is restricted by receptor desensitization, while CNTF alone often induces inflammation and gliosis, limiting its therapeutic potential. This study was aimed at evaluating if a combination of BDNF and CNTF offers synergistic effects, providing superior neuroprotection as compared to either factor alone.

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All our facilities are AAALAC accredited, reflecting our commitment to the highest standards of animal care in research.

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