Intravitreally injected phosphate-buffered saline (PBS) is known to decrease neovascularization in the mouse oxygen-induced retinopathy (OIR) model, and it is commonly used as a vehicle control in preclinical studies evaluating therapeutic efficacy. This study aimed at evaluating the impact of intravitreally (IVT) administered PBS on neovascularization and revascularization at various timepoints after OIR induction. Aflibercept (Eylea®) was used as a reference control.
Cornea is a tight barrier restricting topically administered drugs’ penetration into the eye. The aim of the study was to create a tight epithelial barrier both with primary and with transformed human corneal cells on a 96-well microfluidic platform.
In vitro: Retinal pigment epithelium (RPE) cells exhibit a high susceptibility to reactive oxygen species (ROS) due to their elevated metabolic activity. The accumulation of ROS is a critical factor contributing to the pathogenesis of both dry and wet forms of age-related macular degeneration (AMD). The thioredoxin (TRX) system represents one of the two primary thiol-dependent antioxidant defense mechanisms in mammalian cells. The objective of this study was to investigate the concentration-dependent activation and response of the TRX system to ROS induced by RPE specific exogenous oxidative agent, sodium iodate (NaIO3).
The ARVO 2025 Annual Meeting is just around the corner! Our teams from Finland, Lithuania, and France are getting ready for the trip to Salt Lake City.
Come to meet us in BIO-Europe Spring 2025 in Milan! Our Executive Chairman Giedrius Kalesnykas and CBO Guillaume Demarne are attending the event on March 17-19, 2025.
Experimentica UAB in Lithuania achieved a major accomplishment by receiving a full accreditation from AAALAC International for its outstanding work on animal welfare.
All our facilities are AAALAC accredited, reflecting our commitment to the highest standards of animal care in research.
Copyright: Experimentica Ltd. 2026
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