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ARVO 2025 presentation: Phosphate-buffered saline administered intravitreally at P12 blocks neovascularization in the mouse oxygen-induced retinopathy model

ARVO 2025 presentation: Phosphate-buffered saline administered intravitreally at P12 blocks neovascularization in the mouse oxygen-induced retinopathy model

Intravitreally injected phosphate-buffered saline (PBS) is known to decrease neovascularization in the mouse oxygen-induced retinopathy (OIR) model, and it is commonly used as a vehicle control in preclinical studies evaluating therapeutic efficacy. This study aimed at evaluating the impact of intravitreally (IVT) administered PBS on neovascularization and revascularization at various timepoints after OIR induction. Aflibercept (Eylea®) was used as a reference control.

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ARVO 2025 presentation: Thioredoxin system and HIF1a pathway activation by oxidative stress in human iPSC-RPE cells

ARVO 2025 presentation: Thioredoxin system and HIF1a pathway activation by oxidative stress in human iPSC-RPE cells

In vitro: Retinal pigment epithelium (RPE) cells exhibit a high susceptibility to reactive oxygen species (ROS) due to their elevated metabolic activity. The accumulation of ROS is a critical factor contributing to the pathogenesis of both dry and wet forms of age-related macular degeneration (AMD). The thioredoxin (TRX) system represents one of the two primary thiol-dependent antioxidant defense mechanisms in mammalian cells. The objective of this study was to investigate the concentration-dependent activation and response of the TRX system to ROS induced by RPE specific exogenous oxidative agent, sodium iodate (NaIO3).

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ARVO 2025

ARVO 2025

The ARVO 2025 Annual Meeting is just around the corner! Our teams from Finland, Lithuania, and France are getting ready for the trip to Salt Lake City.

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All our facilities are AAALAC accredited, reflecting our commitment to the highest standards of animal care in research.