Experimentica Ltd. adds optic neuritis model to the Preclinical Model portfolio

Summary: Species: mouseFollow-up period: up to 35 daysRoute of compound administration: topical, intravitreal, systemic. Functional and histological read-outs: In vivo imaging (optical coherence tomography (OCT)); In vivo functional assessment: a) electroretinography (pERG), b) visual evoked potentials (VEP); Morphological assessment (histology, IHC, EM, stereology); Molecular biology (ELISA, Western blotting, qPCR). Reference compounds (for MS-associated and ON phenotypes).

Species: mouse
Follow-up period: up to 35 days
Route of compound administration: topical, intravitreal, systemic.

Functional and histological read-outs:

• In vivo imaging (optical coherence tomography (OCT));
• In vivo functional assessment: a) electroretinography (pERG), b) visual evoked potentials (VEP);
• Morphological assessment (histology, IHC, EM, stereology);
• Molecular biology (ELISA, Western blotting, qPCR).

Reference compounds (for MS-associated and ON phenotypes).