Summary: An alpha1 adrenergic agonist shows preclinical efficacy in a preclinical model for dry eye syndrome
According to the results of a study published in the June 2018 issue of Investigative Ophthalmology and Vision Research, trabodenoson eye drops reduced attenuated hallmark signs of dry-eye disease pathology, including corneal surface inflammation, lacrimal gland infiltration by immune cells and loss of mucin-producing goblet cells in the conjunctiva.
The study, conducted in collaboration with Inotek Pharmaceuticals Corp., K&P Scientific LLC and Loyola University Chicago, compared the preclinical efficacy with a marketed formulation of ophthalmic cyclosporine emulsion and concluded that trabodenoson showed similar or better preclinical efficacy, supporting the development of A1R-targeting pharmaceuticals for DED.
Experimentica Ltd. is a global contract research organization specialized in ocular models. Headquartered in Kuopio, Finland, Experimentica Ltd. focuses on Advancing Ophthalmic Drug DiscoveryTM by offering an industry-leading portfolio for ophthalmic drug development.
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