Meet Us at Bio-Europe 2024!
Experimentica will be presenting preclinical ocular models at Bio-Europe 2024 in Stockholm, Nov. 4-6, 2024.
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Kon’nichiwa BioJapan 2024!
Experimentica will be presenting preclinical ocular models at BioJapan 2024 in Yokohama, Oct. 9-11, 2024.
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Improving corneal permeability of dexamethasone using penetration enhancing agents: first step towards achieving topical drug delivery to the retina
To date, ocular injections and implants are the most effective methods for drug delivery to the back of the eye. However, invasive delivery methods also are costly and risky due to possible complications. In this paper, a novel proprietary polyacetylene polymer and two cell penetrating peptides are compared for topical drug delivery to treat retinal diseases.
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ARVO 2024 presentation: Validating injectable anesthesia for the streptozotocin-induced diabetic retinopathy rat model
Streptozotocin (STZ) induced hyperglycemic rats, commonly used in preclinical diabetic retinopathy (DR) research, have poor response to the most used laboratory rodent anesthesia such as medetomidine/ketamine mixture (MK), and are prone to develop various welfare issues. The purpose of this study was to compare medetomidine/midazolam/butorphanol anesthesia (MMB) to MK in the STZ induced DR rat model to validate injectable anesthesia with less side effects and faster recovery time without compromising the DR development.
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ARVO 2024 presentation: Synthetic Peptide Hydrogel-Based Human In Vitro Corneal Model
Synthetic peptide hydrogels are promising scaffolds where cornea epithelium and other cell types can be grown into in vitro cultures. The aim of this study was to develop a corneal model employing a peptide hydrogel layer as a mimetic of corneal stroma. The model was used in the assessment of corneal cytotoxicity and penetration properties of prostaglandin analogs that are considered as first-line treatment for glaucoma.
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Experimentica Science Day | May 26, 2023, Vilnius, LT
Experimentica Science Day: connect with top preclinical Ophthalmology Professors and Industry Experts for insights and discoveries
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Experimentica-led NeoVasculoStop Consortium Awarded 3 M€ European Innovation Council Pathfinder Grant
Focus is to develop innovative oral treatments for retinal diseases caused by neovascularization and to improve the safety of anti-angiogenic therapies for patients.
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CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity
This study defines ocular adenosine metabolism as a complex and spatially integrated network and further characterizes the critical role of CD73 in maintaining the functional activity of retinal cells.
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Encapsulated xanthohumol protects corneal epithelial cells from DED-associated oxidative stress
Optimization of nanoparticule-based antioxidant formulations with the goal to minimize instillation frequency may represent future therapeutic options for dry eye disease and related ocular surface disease.
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An Efficient In Vitro Cornea Mimetic Model of Testing Drug Permeability
The hydrogel-based human corneal model predicts the rabbit corneal permeability more reliably in comparison to HCE-T cells grown in inserts. This in vitro human corneal model can be successfully employed for drug permeability tests whilst avoiding ethical issues and reducing costs.
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