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Experimentica Ltd. announces the successful acquisition of the Ophthalmic Contract Research Division from Ophthy-DS, Inc.
Experimentica Ltd., a leader in preclinical ophthalmic drug discovery services, announces the successful acquisition of the contract research division from Ophthy-DS, Inc., a Michigan-based preclinical contract research organization (CRO) specializing in non-regulated drug discovery services and medical device testing for ophthalmic indications ... Read More
Ever wondered how Experimentica's scientists refine and improve preclinical ocular models? Join our first webinar series and watch online presentations followed by live discussions of your specific questions and comments ... Read More
Experimental Autoimmune Encephalomyelitis (EAE) is used to study Multiple Sclerosis (MS) a chronic neuroinflammatory demyelinating disorder of the CNS. EAE induces a T cell and mononuclear cell inflammation, which leads to a progressive hind-limb paralysis (Robinson et al., 2014). Due to the severity of EAE, the welfare of animals should be taken into account through the planning of humane endpoints (HEP), providing appropriate perioperative care and minimizing stress factors. Several refinement (3R’s) (W.M.S. Russell and R.L. Burch 1959) methods were tested in order to minimize the number of animals euthanized due to HEP ... Read More
A synthetic metalloporphyrin SOD mimetic protects corneal epithelial cells from oxidative stress-induced damage in vitro and in vivo
Keratoconjunctivitis sicca (KCS) is a multifactorial disease of the lacrimal glands and ocular surface1. Pathological findings in patients with KCS includes a reduction in goblet cells and the presence of inflammatory cell infiltrates in the lacrimal glands2. KCS usually involves tear hyperosmolarity and ocular surface inflammation. Increased tissue levels of reactive oxygen species (ROS) and the ensuing oxidative stress are common hallmarks KCS and thought to contribute to the associated ocular surface damage. Superoxide dismutases (SODs) are enzymes which are part of antioxidant system that protects against ROS through dismutation of superoxide to produce hydrogen peroxide2,3. The aim of this study was to determine the efficacy of Mn-TM-2-PyP (metalloporphyrin SOD mimetic) against oxidative-stress induced damage in corneal epithelial cells in in vitro, and in the SiccaSystemTM in vivo model ... Read More