Neuroprotection

All models

Listed alphabeticly

A

Assessment of toxicity responses in human retinoblastoma cells 

Assessment of toxicity responses in human retinoblastoma cells 

An assessment and prediction tool of a drug-induced toxicity on human retinoblastoma cells.

Related In Vitro Tolerability and Toxicity

Neuroprotection

Assessment of toxicity responses in primary cortical neurons

Assessment of toxicity responses in primary cortical neurons

An assessment and prediction of drug-induced neuroprotection and toxicity in rat primary cortical neurons.

Related In Vitro Tolerability and Toxicity

Neuroprotection

E

Ex Vivo Retinal Wholemount

Ex Vivo Retinal Wholemount

Organotypic retinal tissue ex vivo provides a simplified model to study retinal cell degeneration and screen promising drugs.

Related Ex Vivo

Neuroprotection

Retinitis Pigmentosa

Experimental Autoimmune Encephalomyelitis (EAE)

Experimental Autoimmune Encephalomyelitis (EAE)

EAE models aspects of autoimmunity, inflammation, demyelination, cell trafficking and tolerance induction seen in Multiple Sclerosis.

Related In Vivo

Inflammation

Neuroprotection

G

Glaucoma, Ocular Hypertension (intraocular pressure, IOP)

Glaucoma, Ocular Hypertension (intraocular pressure, IOP)

Induced elevation of IOP is widely used as an experimental approach to mimic glaucoma pathology in animals.

Related In Vivo

Glaucoma

Neuroprotection

L

Light Damage – Blue Light Damage

Light Damage – Blue Light Damage

The rodent blue light damage (BLD) model is a well-established model for retinal degeneration, oxidative stress and neuroinflammatory activity.

Related In Vivo

AMD - All models

AMD - Dry AMD

AMD - Geographic Atrophy

AMD - Stargardt Disease

More+ Less -

Light Damage – White Light Damage

Light Damage – White Light Damage

Bright light retinal damage in rodents remains one of the most widely used models mimicking human retinal degenerations such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD).

Related In Vivo

AMD - All models

AMD - Dry AMD

AMD - Geographic Atrophy

AMD - Stargardt Disease

More+ Less -

N

Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)

NAION-like pathology induction leads to an acute ischemia and to edema, inflammation, and acute loss of retinal ganglion cells (RGCs) and optic nerve axons.

Related In Vivo

Neuroprotection

Retina

Retinal ischemia

O

Optic Nerve Crush (ONC)

Optic Nerve Crush (ONC)

Crushing the optic nerve with mechanical damage leads to axon degeneration, in turn inducing the apoptotic process in RGCs and, eventually, RGC loss, mimicking glaucomatous neuropathies.

Related In Vivo

Glaucoma

Neuroprotection

R

Retinal Detachment model

Retinal Detachment model

Retinal detachment happens in AMD, Diabetic Retinopathy, and Retinopathy of Prematurity.

Related In Vivo

AMD - All models

Diabetic Retinopathy

Fibrosis

Inflammation

More+ Less -

S

Sodium iodate retinal degeneration

Sodium iodate retinal degeneration

NaIO3-induced retinal degeneration is widely used to study cell death in AMD. This results in death of retinal pigmented epithelium followed by a secondary death of photoreceptors, similar to what is observed in Geographic Atrophy.

Related In Vivo

AMD - All models

AMD - Dry AMD

AMD - Geographic Atrophy

Neuroprotection