AMD – All models
All models
Listed alphabeticly
DSodium iodate retinal degeneration
Sodium iodate retinal degeneration
NaIO3-induced retinal degeneration is widely used to study cell death in AMD. This results in death of retinal pigmented epithelium followed by a secondary death of photoreceptors, similar to what is observed in Geographic Atrophy.
VEGF-induced Retinal Leakage
VEGF-induced Retinal Leakage
The up-regulation of VEGF leads to abnormal retinal vascular growth and leakage that causes visual impairment. Intravitreal injection of VEGF causes a transient retinal leakage mimicking the like of wet AMD and diabetic retinopathy.